Anti-CBX2 Antibody

CBX2 (Chromobox homolog 2) is a chromodomain-containing subunit of the Polycomb Repressive Complex 1 (PRC1) that reads trimethylated histone H3 Lys27 (H3K27me3) marks, supporting chromatin compaction and transcriptional silencing of developmental and tumor-suppressor genes.

Supplied by Antibodies.com as a 50 µL aliquot, this rabbit polyclonal IgG reagent was raised against CBX2 and is validated for Western blot detection of the endogenous human protein in cell and tissue lysates. The unconjugated format supports downstream chromogenic, fluorescent, or chemiluminescent immunoblotting workflows, while the polyclonal backbone allows recognition of multiple epitopes across the CBX2 polypeptide.

Researchers investigating Polycomb-mediated gene repression, X-chromosome inactivation, spermatogenesis, or the PRC1/H3K27me3 axis in cancer biology routinely apply anti-CBX2 antibodies to chromatin fractionation, immunoprecipitation, and expression-profiling studies in mammalian systems. For best results, refrigerate the antibody in single-use portions and limit freeze-thaw cycles to preserve binding activity across multiple experiments.