Anti-CBR3 Antibody

This rabbit polyclonal antibody from Antibodies.com targets human Carbonyl Reductase 3 (CBR3), a cytosolic NADPH-dependent oxidoreductase belonging to the short-chain dehydrogenase/reductase (SDR) superfamily. CBR3 catalyzes the reduction of a broad range of carbonyl substrates, including endogenous steroid metabolites, lipid-derived aldehydes, and xenobiotic ketones, and is expressed at varying levels across liver, kidney, lung, and brain tissues.

Supplied as an unconjugated polyclonal reagent in a 100 µl volume, the antibody is validated for Western blot and immunohistochemistry workflows on human samples. Researchers studying CBR3 use it to probe protein expression in tumor tissue sections, investigate doxorubicin and anthracycline metabolism in hepatic and renal models, and characterize carbonyl-substrate handling in drug-response studies.

The polyclonal format yields recognition of multiple epitopes across the CBR3 protein, which improves tolerance to minor denaturation differences between sample preparations. The unconjugated format lets researchers pair the reagent with their preferred secondary detection system, whether HRP, alkaline phosphatase, or fluorescent labels, depending on the assay platform.