Anti-CBLB Antibody

The CBLB (Casitas B-lineage lymphoma proto-oncogene b) target is a RING-type E3 ubiquitin ligase widely studied for its role as a negative regulator of T-cell receptor signaling, anergy induction, and immune tolerance maintenance. This unconjugated, rabbit-derived polyclonal reagent from Antibodies.com is supplied as 100 µl of liquid and is validated for western blot and immunohistochemistry workflows on human, mouse, and rat samples.

Because the antibody is unconjugated, it integrates cleanly into custom detection pipelines, allowing researchers to pair it with HRP-, biotin-, or fluorophore-labeled secondary reagents depending on assay needs. Its polyclonal nature supports recognition of multiple epitopes on CBLB, which can be useful when probing protein isoforms, post-translational modifications, or partial degradation products in signaling studies.

Typical research applications include examining CBLB expression in lymphoid tissues, characterizing its regulatory interactions with VAV, PI3K, and CRKL adaptor proteins, and exploring its involvement in autoimmune disease models, transplant rejection studies, and tumor immunology research. For long-term use, the antibody is generally kept frozen in working aliquots to limit freeze-thaw cycles and preserve reactivity across repeated experiments.