Anti-CBLB Antibody

CBLB (Cbl proto-oncogene B) is an E3 ubiquitin-protein ligase that negatively regulates signalling downstream of receptor tyrosine kinases and modulates T-cell receptor activation in T lymphocytes, and this rabbit polyclonal primary antibody from Antibodies.com is raised against the endogenous human, mouse, and rat protein. The unconjugated reagent is supplied as 100 µl of a 1 mg/ml stock in PBS with 0.1% sodium azide and 50% glycerol and is validated for Western blot (WB) and immunohistochemistry (IHC), making it useful for cross-species studies of immune-cell anergy, ubiquitin-mediated turnover of surface receptors, and signalling in primary cells and tissue sections. The polyclonal format allows recognition of multiple epitopes on the CBLB protein, which is helpful when endogenous expression is low or when post-translational modification may mask single epitopes. Aliquot the stock upon arrival and freeze at -20 °C for long-term storage, thawing only what is needed to limit repeated freeze-thaw cycles and preserve the 50% glycerol cryoprotectant. Sodium azide (0.1%) is included as a preservative, so each 100 µl vial is intended as a single-use format suitable for bench-top immunostaining, lysate probing, and tissue-section work in basic-research settings only.