Anti-Cbl (phospho-Y700) Antibody

Phosphorylation of the Cbl E3 ubiquitin ligase at tyrosine 700 is a tightly regulated signaling event downstream of Src family kinases, receptor tyrosine kinases, and T-cell receptor activation, making this residue a useful marker for studying negative-feedback control of growth factor and immune pathways.

This rabbit polyclonal phospho-specific reagent is supplied unconjugated at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, and is provided in a 100 µl vial ready for use in Western blot, immunohistochemistry, and immunofluorescence workflows.

The Cbl (phospho-Y700) antibody from Antibodies.com reacts with human, mouse, and rat samples and is used to monitor site-specific phosphorylation in cell lysates and tissue sections, supporting studies of oncogenic signaling, immune cell activation, and receptor downregulation.

The 50% glycerol cryoprotective buffer is suited for frozen storage; aliquot on receipt to limit repeated freeze-thaw cycles and protect reagent activity.