Anti-CBFB Antibody

The CBFB protein (Core-Binding Factor Subunit Beta) forms a heterodimer with RUNX1/AML1 and is essential for definitive hematopoiesis. Chromosomal rearrangements involving CBFB, including the inv(16) inversion that generates the CBFB-MYH11 fusion, are recurrent drivers of acute myeloid leukemia, which is why this target is widely studied in leukemia biology and transcriptional regulation research.

This polyclonal reagent from Antibodies.com is raised in rabbit and supplied as 100 µl of unconjugated antiserum in a vial format. It is reactive against human, mouse, and rat samples and has been validated for western blot, immunohistochemistry, and immunofluorescence workflows. The unconjugated format gives laboratories flexibility to pair the primary antibody with their preferred secondary reagent and detection chemistry, including fluorescent, chromogenic, and chemiluminescent readouts.

Typical applications include probing RUNX1/CBFB-dependent transcriptional programs in hematopoietic cell lines, mapping CBFB expression patterns in normal versus malignant bone marrow tissue by IHC, and tracking CBFB-MYH11 fusion protein behavior in cell-based models of inv(16) AML through immunofluorescence and western blot analysis.