Anti-CBFA2T2 Antibody

This Rabbit polyclonal antibody from Antibodies.com targets CBFA2T2, a member of the ETO family of transcriptional co-repressors that interacts with AML1/RUNX1 and plays a regulatory role in hematopoietic gene expression. The unconjugated reagent is supplied as a 100 µl volume suited to Western blot (WB) and Immunofluorescence (IF) workflows on human samples, and was raised in Rabbit host to deliver polyclonal recognition of the native target protein.

CBFA2T2 (also referenced in the literature as MTGR1 or EHT) has been studied in the context of acute myeloid leukemia and normal blood cell development, where its association with RUNX1 family partners influences transcriptional repression at target promoters. Researchers using this reagent typically work with whole-cell lysates for WB band detection around the expected molecular weight, or with fixed cells for IF localization studies, where the protein is reported to concentrate in the nuclear compartment.

For storage, aliquot the antibody upon receipt and store at -20°C in a frost-free freezer; avoid repeated freeze-thaw cycles to preserve polyclonal reactivity. Each lot from Antibodies.com is validated for the listed applications, and the unconjugated format leaves the choice of secondary antibody and detection chemistry (chromogenic, fluorescent, or chemiluminescent) to the individual experimental design.