Anti-Caveolin-3 Antibody

This recombinant rabbit monoclonal antibody specifically recognizes Caveolin-3 (CAV3), the muscle-specific membrane protein that forms the structural backbone of caveolae in skeletal and cardiac tissue. Produced as an unconjugated reagent at a 100 µL size, the antibody is formulated in TBS buffer (pH 7.4) supplemented with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative, and should be stored frozen at -20°C for long-term stability, with aliquots recommended to minimize freeze-thaw cycles.

Validated for Western blot detection across human, mouse, and rat samples, the reagent is widely cited in research on caveolae biology, sarcolemmal membrane organization, and the molecular basis of muscle disease. Investigators studying limb-girdle muscular dystrophy type 1C (LGMD1C), rippling muscle disease, idiopathic hyperCKemia, and CAV3-associated cardiomyopathies use anti-Caveolin-3 antibodies to assess protein expression, membrane localization, and oligomerization status in myotubes and cardiomyocyte models. Researchers evaluating dystrophin-glycoprotein complex integrity and mechanical stress signaling in striated muscle also rely on this marker.

Provided by Antibodies.com, each lot is generated from a recombinant rabbit host system, ensuring batch-to-batch consistency and clonality for reproducible immunoblot band detection near the expected molecular weight of approximately 17 kDa. The unconjugated format allows flexible pairing with HRP, fluorophore, or biotin secondary reagents depending on experimental design.