Anti-Caveolin-1 Antibody

This unconjugated monoclonal antibody from Antibodies.com targets Caveolin-1, a 21-24 kDa scaffolding protein that organizes lipid raft microdomains called caveolae and modulates signal transduction at the plasma membrane. The reagent is supplied as 100 µl of mouse IgG1 in 1×TBS buffer (pH 7.4) supplemented with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative, a format suited to repeated withdrawal for ongoing western blot, immunocytochemistry, and immunohistochemistry workflows. Clonality is monoclonal, host species is mouse, and the conjugate is unconjugated, leaving the antibody available for downstream labelling with HRP, fluorophores, or biotin depending on the detection chemistry required.

Caveolin-1 is broadly expressed across epithelia, endothelium, fibroblasts, and many transformed cell lines, and researchers rely on it to study caveolae-mediated endocytosis, mechanotransduction, cholesterol homeostasis, receptor tyrosine kinase signaling, and tumor-stroma interactions in cancer biology. The reagent is validated for use on human, mouse, and rat samples, covering standard cell culture models, primary tissue sections, and archived paraffin-embedded specimens used in IHC. For best stability, store the vial at 4 °C short term; the glycerol-containing formulation tolerates standard refrigerator storage without freeze-thaw cycling, which preserves epitope recognition across multiple experiments.