Anti-Cathepsin S Antibody

This polyclonal antibody from Antibodies.com is raised in rabbit and binds human Cathepsin S, a lysosomal cysteine protease of the papain family that mediates invariant chain cleavage during MHC class II antigen presentation and contributes to extracellular matrix remodeling. The unconjugated reagent is provided in a 100 µl volume for western blot and immunohistochemistry workflows on human tissue and cell samples. The target appears as the proenzyme near 37 kDa, with the mature heavy chain resolving around 24-28 kDa under reducing conditions. Cathepsin S is expressed in professional antigen-presenting cells such as dendritic cells, macrophages, and B lymphocytes, and it is also reported in tissues undergoing proteolytic remodeling, including atherosclerotic plaques and tumor microenvironments. Investigators apply the antibody to profile immune activation, cardiovascular disease models, and cancer invasion studies where cysteine protease activity is a focus.