Anti-Catenin-γ Antibody

Plakoglobin, the protein recognized by this Rabbit polyclonal reagent, is a junctional component of both desmosomes and adherens junctions in epithelial and cardiac tissue, and also functions as a transcriptional co-activator in the canonical Wnt signaling cascade.

Antibodies.com supplies this Anti-Catenin-γ antibody in an unconjugated format, packaged as 100 µl of ready-to-use reagent validated for Western blot and immunohistochemistry workflows. Raised in Rabbit, the antibody cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies of desmosomal assembly, cardiomyocyte junction integrity, and downstream Wnt pathway readouts.

Investigators working on arrhythmogenic right ventricular cardiomyopathy or Naxos disease, where JUP/plakoglobin loss-of-function mutations are implicated, routinely employ this reagent for lysate-based and tissue-level detection of the endogenous target. Unconjugated presentation allows downstream flexibility, including pairing with user-selected fluorophore- or enzyme-conjugated secondary reagents for immunofluorescence, chromogenic IHC, or standard Western blot chemiluminescence.