Anti-Catenin-γ Antibody

Catenin-γ (plakoglobin), encoded by the JUP gene, is a key structural component of both desmosomes and adherens junctions, mediating calcium-dependent cell-cell adhesion in epithelial and cardiac tissue. This unconjugated primary antibody from Antibodies.com is raised in rabbit as a polyclonal reagent and is supplied as 100 µl of ready-to-use stock in a single vial.

Validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows, the reagent detects the gamma-catenin target across human, mouse, and rat samples. Researchers commonly apply it to studies of desmosomal assembly, epithelial-mesenchymal transition, and cardiomyopathy-associated junction remodeling, where plakoglobin mislocalization or loss is used to flag structural defects in intercalated discs and stratified epithelia.

For best results, aliquot upon first thaw to limit freeze-thaw cycles and store at -20°C in a frost-free unit, protecting the vial from light. The unconjugated format leaves the choice of reporter open, allowing flexible pairing with custom fluorophore or enzyme conjugates and with secondary detection reagents tailored to a given assay platform.