Anti-Catenin-β Antibody

Raised in rabbit, this polyclonal primary antibody targets Catenin-β, the dual-role protein central to canonical Wnt signal transduction and to cadherin-mediated cell-cell adhesion at the plasma membrane.

Produced by Antibodies.com as an unconjugated reagent supplied at 100 µl per vial, the antibody recognizes human, mouse, and rat β-catenin and is validated for Western blot, immunohistochemistry, and ELISA workflows.

β-catenin accumulates in the cytoplasm and translocates to the nucleus where it partners with TCF/LEF transcription factors, and the antibody is commonly used to track this redistribution in cancer research models such as colorectal and hepatocellular carcinoma, as well as in studies of epithelial-mesenchymal transition and stem cell maintenance.

Aliquot upon first use and store at -20°C in a frost-free freezer to preserve binding activity across multiple freeze-thaw cycles.

The polyclonal format offers recognition of multiple epitopes, which is helpful when probing post-translationally modified or truncated forms of β-catenin that arise from APC or AXIN pathway mutations.