Anti-Catenin-β1 Antibody

Primary antibody reagents targeting the Wnt/β-catenin signaling pathway are indispensable for research into cadherin-mediated cell adhesion, embryonic development, and oncogenic transcription. This unconjugated rabbit polyclonal reagent from Antibodies.com recognizes the CTNNB1-encoded β-catenin protein, supporting western blot and immunohistochemistry workflows on human, mouse, and rat samples. The target protein migrates at approximately 85 kDa on SDS-PAGE and shuttles between cytoplasmic and nuclear compartments depending on Wnt pathway activity, where it partners with TCF/LEF transcription factors to drive expression of downstream target genes such as cyclin D1 and c-Myc.

Supplied as a 100 µl vial of polyclonal serum, the reagent offers multi-epitope recognition useful for studying protein variants, phosphorylation states (including GSK-3β-mediated Ser33/Ser37/Thr41 modifications), and truncated forms observed in malignancy. Applications include characterization of colorectal and hepatocellular carcinoma models, intestinal stem cell maintenance, epithelial-mesenchymal transition studies, and cytoskeletal anchoring at adherens junctions. Aliquot upon arrival and refrigerate for short-term use; for longer storage, freeze in working aliquots and limit freeze-thaw cycles to preserve antibody binding activity.