Anti-Catenin-β (F660) Antibody

Beta-catenin (CTNNB1) functions as both a structural component of the cadherin-catenin adhesion complex at the plasma membrane and a nuclear transcriptional co-activator in the canonical Wnt signaling cascade. This rabbit polyclonal antibody from Antibodies.com recognizes an epitope flanking the F660 residue of human beta-catenin and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows on samples from human, mouse, and rat origins. Supplied as a 50 µl aliquot at 1 mg/ml in phosphate buffered saline (pH 7.2) with 15 mM sodium azide as a preservative, the unconjugated reagent is suited to studies of Wnt-driven transcription, colorectal and hepatocellular carcinoma pathology, epithelial-mesenchymal transition, and developmental patterning. Researchers commonly deploy it to track subcellular redistribution between membrane, cytoplasmic, and nuclear pools, and to detect truncated or mutant forms that escape proteasomal degradation, making it a versatile reagent for cell culture, fixed tissue, and lysate-based investigations.