Anti-Catenin-β Antibody

β-catenin is a multifunctional protein best known for its dual role in cadherin-mediated cell adhesion at the plasma membrane and as the central transcriptional co-activator of the canonical Wnt signaling pathway. This recombinant rabbit monoclonal antibody from Antibodies.com recognizes Catenin-β in human, mouse, and rat samples, providing a single-clone reagent for tracking the protein across those model systems.

Researchers use it to follow β-catenin's shifting distribution between membrane, cytoplasmic, and nuclear pools, a redistribution that is a hallmark of Wnt pathway activation and a frequent feature of colorectal, hepatocellular, and other epithelial cancers. The unconjugated format leaves the antibody open to pairing with a secondary reagent of the user's choice for fluorescence, chromogen, or chemiluminescence readouts.

Supplied as 50 µl per vial in TBS buffer (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative, the glycerol-rich formulation tolerates repeated freeze-thaw cycles and is intended for frozen storage at -20°C. The reagent is validated for western blot, immunocytochemistry, immunohistochemistry, and immunoprecipitation, covering the main readouts needed to study endogenous β-catenin localization, post-translational modifications, and interaction partners in cell and tissue lysates. The monoclonal format reduces lot-to-lot variability and minimizes background compared with typical polyclonal sera, which is particularly useful when distinguishing nuclear from membrane staining patterns.