Anti-CAST Antibody

Calpastatin (CAST) is the endogenous, specific inhibitor of calpain cysteine proteases, regulating their activity across muscle protein turnover, apoptosis signaling, and neuronal calcium handling. This unconjugated rabbit polyclonal reagent from Antibodies.com binds CAST and supports Western blot and immunohistochemistry workflows on human-derived samples. The 100 µL volume accommodates multiple membrane probing experiments or a sizeable panel of fixed tissue sections, and the polyclonal backbone provides broader epitope coverage useful when probing full-length calpastatin isoforms rather than a single linear determinant. Laboratories investigating muscle wasting, neurodegeneration, or calpain–calpastatin balance in disease models use such reagents to detect endogenous CAST expression, monitor proteolytic regulation, or confirm knockout efficiency at the protein level.