Anti-CaSR (A884) Antibody

The Calcium-Sensing Receptor (CaSR) is a class C G-protein-coupled receptor central to extracellular calcium homeostasis, parathyroid hormone regulation, and renal calcium handling. Mutations in the CASR gene are linked to familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalemia, making well-characterized immunological reagents valuable for translational research.

This Anti-CaSR (A884) Antibody from Antibodies.com is a rabbit polyclonal reagent raised against the calcium-sensing receptor, supplied as 100 µl of unconjugated antibody at 1 mg/ml in phosphate-buffered saline containing 0.05% sodium azide at approximately pH 7.2. The antibody is validated for western blot (WB) and immunohistochemistry (IHC) workflows, and shows reactivity against human, mouse, and rat CaSR, supporting cross-species studies in tissue sections and lysates.

Applications include western blotting to detect CaSR protein expression in cell or tissue lysates, and immunohistochemistry for localization studies in parathyroid, kidney, bone, and other calcium-regulating tissues. The unconjugated format allows pairing with a secondary detection reagent of choice, including HRP-, biotin-, or fluorophore-conjugated anti-rabbit secondaries. Store refrigerated in the supplied buffer; aliquot to limit freeze-thaw cycles and protect from light to maintain antibody stability.