Anti-Caspase-7 p20 (D198) Antibody

Affinity-purified polyclonal antibody raised in rabbit against the cleaved large subunit (p20) of human Caspase-7, generated at the Asp198 processing site during apoptotic activation. The antibody specifically recognizes the mature, proteolytically processed 20 kDa fragment rather than the full-length zymogen, making it a useful reagent for monitoring executioner caspase activation. Validated for Western blot and immunohistochemistry across human, mouse, and rat samples.

Supplied as 100 µl of a 1 mg/ml stock in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant. Store at -20 °C in aliquots to limit freeze-thaw cycles and protect from light to preserve binding activity. This unconjugated reagent from Antibodies.com can be paired with HRP-, biotin-, or fluorophore-conjugated secondary antibodies for chemiluminiscent, chromogenic, or immunofluorescence readouts in cell lysates and formalin-fixed tissue sections.

Recommended for apoptosis research profiling executioner caspase activity, including PARP and lamin cleavage readouts, and for distinguishing initiator versus effector caspase signaling in tumor biology, neurodegeneration models, and developmental cell death studies.