Anti-Caspase-7 Antibody

This rabbit polyclonal reagent from Antibodies.com targets Caspase-7, a cysteine-aspartic protease that functions as an executioner caspase during apoptotic cell death. The antibody is supplied unconjugated in a 100 µl format, supporting direct use in Western blot and ELISA workflows. Caspase-7 operates downstream of initiator caspases and shares substrate preference with caspase-3, cleaving poly(ADP-ribose) polymerase and other death-associated substrates, which makes detection of its processing a useful readout for intrinsic and extrinsic apoptotic signaling. The polyclonal configuration raises the probability of recognizing multiple epitopes across the full-length proenzyme (~35 kDa) and the cleaved large subunit (~20 kDa), enabling researchers to monitor both the inactive zymogen and its activated form in the same blot. Reactive with human samples, the reagent is widely used in research programs exploring cancer biology, neurodegeneration, and drug-induced cytotoxicity, where caspase activation serves as a quantifiable endpoint. For best results, aliquot upon receipt, protect from light where applicable, and limit freeze-thaw cycles by storing refrigerated for working volumes while keeping a frozen stock for long-term use.