Anti-CASP8AP2 Antibody

Raised in rabbit against CASP8AP2 (caspase 8 associated protein 2), this unconjugated polyclonal reagent from Antibodies.com is validated for western blot and immunohistochemistry workflows on human samples. CASP8AP2, also known as FLASH, localizes to nuclear structures called histone locus bodies and supports histone mRNA 3'-end processing during S phase. The protein additionally recruits caspase-8 to death effector filaments, linking chromatin-related transcription and processing activity to the extrinsic apoptosis pathway.

The antibody is supplied as 100 µl of polyclonal serum fraction in a vial, unconjugated and free of carrier proteins that would interfere with downstream detection chemistries. Researchers in cell biology, cancer signaling, and chromatin regulation laboratories apply this reagent to characterize FLASH/CASP8AP2 expression in fixed tissue sections and to confirm the protein's apparent molecular weight by western blot. Host species reactivity is restricted to human targets, and the polyclonal format offers broader epitope coverage than a monoclonal reagent for detecting this large, multidomain nuclear factor.