Anti-CASP2 Antibody

Produced by Antibodies.com as a rabbit polyclonal reagent, this unconjugated IgG preparation targets CASP2 (also known as ICH1, NEDD2, MGC2181, and PPP1R57), a cysteine-aspartic acid protease (Gene ID 12366) that functions in death-receptor and stress-induced apoptotic signaling upstream of mitochondrial outer membrane permeabilization. The 100 µl volume of affinity-purified antiserum enables detection of both the full-length pro-caspase 2 protein and its cleaved subunits, supporting studies that resolve activation-state dynamics across model systems. The reagent has been validated for western blot, immunohistochemistry, and flow cytometry workflows on human and mouse samples, including applications in oncology and neurodegeneration research where caspase 2 activity is mapped across tumor cell lines, primary neuronal cultures, and fixed tissue sections. Polyclonal reactivity toward multiple epitopes within the target gives reproducible coverage of the protein across these experimental formats. Aliquot upon first use to limit freeze-thaw exposure and keep refrigerated between uses; the vial format allows convenient storage and is intended for research use only, not for diagnostic or therapeutic procedures.