Anti-CASP1 Antibody

Caspase-1 (CASP1) is a cysteine-aspartic acid protease that initiates inflammatory cytokine maturation and drives pyroptotic cell death through inflammasome assembly. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against human CASP1 and is validated for Western blot and immunohistochemistry workflows in research settings.

The antibody is supplied as 100 µl of ready-to-use reagent in a vial, providing sufficient volume for multiple membrane and tissue-staining assays. Because caspase-1 sits at the apex of inflammasome signaling and cleaves pro-IL-1β and pro-IL-18 into their bioactive forms, the reagent is widely used to probe inflammatory signaling, innate immune activation, and programmed cell death pathways in human tissue and cell-line samples.

For storage, the antibody should be kept refrigerated with aliquots prepared to limit freeze-thaw cycles and protect the polyclonal preparation from loss of titre. Researchers applying it to Western blot typically detect the pro-caspase-1 band near 45 kDa, while IHC use benefits from antigen retrieval protocols appropriate to the fixation method. Each lot is produced under quality-controlled conditions to support reproducible detection of endogenous CASP1 in human samples.