Anti-CASK Antibody

CASK (Calcium/Calmodulin-Dependent Serine Protein Kinase) is a MAGUK-family scaffolding protein critical for synaptic assembly, neurotransmitter receptor trafficking, and neuronal signaling. This rabbit polyclonal antibody from Antibodies.com detects endogenous CASK in both human and mouse samples, providing a versatile tool for neuroscience and cell biology research laboratories.

Supplied as 100 µl of unconjugated polyclonal antiserum raised in rabbit, the reagent supports Western Blot (WB) and Immunohistochemistry (IHC) workflows. Common applications include probing synaptic density fractions, characterizing CASK localization in brain tissue sections, validating knockout or knockdown models, and mapping expression patterns across developing and adult neural tissue.

CASK localizes to neuronal synapses, where it interacts with binding partners such as Mint1, Veli, and neurexins, and can shuttle into the nucleus to modulate TBR1-dependent transcription. Researchers studying X-linked intellectual disability, pontine and cerebellar hypoplasia, or synaptic plasticity frequently turn to this reagent. The unconjugated format enables flexible secondary antibody pairing across fluorescent and chemiluminescent detection platforms.