Anti-CASC3 Antibody

CASC3 (Cancer Susceptibility 3), also known as MLN51, is a core component of the exon junction complex that assembles on spliced mRNAs and contributes to nuclear mRNA export, subcellular mRNP remodeling, and nonsense-mediated decay. This unconjugated rabbit polyclonal IgG antibody binds the endogenous human CASC3 protein and is supplied by Antibodies.com as a 200 µl liquid aliquot. It is validated for Western blot and immunohistochemistry workflows on human specimens, supporting studies of EJC deposition, splicing-dependent mRNA surveillance, and altered CASC3 expression reported in several tumor types. The polyclonal format presents multiple epitopes on the target, which improves recognition of the full-length protein across lysate preparations and fixed tissue sections, while the unconjugated IgG format gives downstream flexibility: investigators can pair it with species-matched secondary reagents of their choice, or conjugate it directly for custom assays. Affinity-purified material is shipped refrigerated and is intended for research use only, not for diagnostic procedures.