Anti-CARM1 (Ab-228) Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com recognizes CARM1 (also known as PRMT4, the type I coactivator-associated arginine methyltransferase) in a region that includes residue 228. The reagent is supplied as 100 µl of liquid and is validated for Western blot and immunofluorescence applications.

CARM1/PRMT4 deposits asymmetric dimethyl marks on histone H3 at residue Arg26 (H3R26me) and modifies non-histone substrates, linking chromatin remodeling to nuclear-receptor signaling, p53 activation, and RNA splicing. It is therefore a frequent target in studies of estrogen receptor-driven transcription, skeletal muscle differentiation, and tumor cell proliferation.

Cross-reactivity is reported for human, mouse, and rat samples, enabling comparative work across established cell lines and primary tissue. The polyclonal format recognizes multiple epitopes within the target region, which helps when post-translational modification or fixation is suspected to mask a single site. Refrigerate upon receipt, aliquot to limit freeze-thaw cycles, and protect from light to preserve long-term activity.