Anti-Carbonic Anhydrase IX Antibody

Carbonic Anhydrase IX (CA IX) is a hypoxia-induced transmembrane zinc metalloenzyme encoded by the CA9 gene, widely studied as a tissue marker because its expression rises sharply under HIF-1α-driven signaling. The Antibodies.com clone is a mouse monoclonal IgG, unconjugated and supplied as 100 µl of ready-to-titer liquid, validated for Western Blot and Immunoprecipitation on human samples. Investigators apply the antibody to confirm CA IX overexpression in clear cell renal cell carcinoma — the textbook diagnostic context for this biomarker — and to map the same response in glioblastoma, cervical, breast, and lung tumor models, where acidic microenvironments drive enzyme induction. Because the reagent is unconjugated, lab teams select HRP, fluorophore, or biotin-labeled secondaries matched to their chemiluminescence, fluorescence, or affinity detection chemistry. Specific to human CA IX, the vial is shipped under refrigerated conditions and is intended for research use only, supporting hypoxia signaling studies, tumor biology pipelines, and biomarker discovery work.