Anti-CAPZA2 Antibody

Produced in rabbit as an unconjugated polyclonal preparation, this primary antibody from Antibodies.com targets CAPZA2, the alpha-2 subunit of the heterodimeric CapZ capping complex that binds the barbed ends of actin filaments and gates actin polymerization dynamics. CAPZA2 concentrates at the Z-disc of striated muscle, where it stabilizes sarcomeric architecture and anchors thin-filament length during contraction cycles. The reagent is supplied as 100 µl of affinity-purified antisera, validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows.

Confirmed reactivity across human, mouse, and rat samples makes this antibody useful for comparative cytoskeletal studies in cardiomyocytes, skeletal muscle fibers, and non-muscle cell models where actin remodeling is under investigation. Typical applications include tracking CAPZA2 abundance during myogenic differentiation, mapping Z-disc morphology in tissue sections, and resolving subcellular localization of the protein at sarcomeric boundaries. For handling, store the vial refrigerated, protect the contents from light, and aliquot upon first use to limit freeze-thaw cycles across multi-week experimental timelines.