Anti-CapZ-beta Antibody

Investigate cytoskeletal regulation in muscle and non-muscle cells with this rabbit polyclonal antibody from Antibodies.com, which targets the CapZ-beta subunit (CAPZB) of the heterodimeric capping protein complex. Supplied as a 100 µl aliquot of unconjugated, affinity-purified IgG, the reagent is validated for Western blot and immunohistochemistry on human samples. The CAPZB gene maps to chromosome 1p36.13 and encodes an approximately 31 kDa polypeptide that localizes to sarcomeric Z-discs in striated muscle and to cortical actin networks in non-muscle cells, where it terminates the barbed (fast-growing) ends of actin filaments and restrains unregulated filament polymerization. Variants in CAPZB have been described in patients with congenital myopathy, and the protein is broadly implicated in sarcomere assembly, cardiomyocyte Z-line maintenance, and directed cell migration. The polyclonal format enables multi-epitope recognition of the target, supporting reproducible single-band detection at the expected molecular weight on blots and consistent cytoplasmic or Z-disc staining patterns in fixed tissue sections.