Anti-CAPN6 Antibody [Assigned #A3775]

This mouse monoclonal IgG reagent from Antibodies.com targets calpain-6 (CAPN6), an atypical member of the calcium-dependent cysteine protease family that lacks intrinsic catalytic activity because key active-site residues are substituted. Clone A3775 is supplied as 100 µl of unconjugated antibody in a single-use vial and is validated for Western Blot detection of human CAPN6, supporting investigations of embryonic development, placental biology, and tumour biology settings where altered CAPN6 expression has been documented.

The antibody is raised in mouse and prepared as an IgG isotype preparation. For handling, store the vial refrigerated and protect from light; aliquot before long-term storage and limit freeze-thaw cycles to preserve binding activity. Because calpain-6 is a catalytically dead protease thought to function through protein-protein interactions rather than proteolysis, researchers commonly probe its band by Western blot to compare signal intensity across cell lines and tissue lysates, including studies of uterine mesenchymal neoplasms in which elevated CAPN6 transcript abundance has been reported in the literature.