Anti-CAPN5 Antibody

Raised in rabbit against the calpain-5 (CAPN5) protein, this polyclonal antibody from Antibodies.com targets a calcium-dependent intracellular cysteine protease whose gene is mutated in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV). Altered CAPN5 activity has also been reported in several tumor cell lines, making this reagent broadly useful for studies of retinal degeneration, protease biology, and cancer cell biology.

Supplied as a 100 µl liquid at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated Ig is ready for standard immunodetection workflows. Validated applications include Western blot (WB) and immunohistochemistry (IHC), and the antibody has been confirmed to react with both human and mouse samples, covering the most widely used mammalian research models. For best stability, store the vial at -20 °C in working aliquots and limit freeze-thaw cycles; the glycerol-containing buffer keeps the antibody liquid at the bench for short-term use.

Researchers probing calpain family proteolysis, photoreceptor survival, vitreoretinal inflammation, or comparative mouse models of human retinal disease will find this a versatile primary reagent for both denaturing gels and fixed tissue sections.