Anti-CAPN3 Antibody

Rabbit polyclonal antibody targeting calpain-3 for muscle research

Calpain-3 (CAPN3, also called p94) is a calcium-dependent cysteine protease highly expressed in skeletal muscle, and loss-of-function variants cause limb-girdle muscular dystrophy type 2A (LGMD2A / RBM1). This unconjugated rabbit polyclonal IgG reagent binds the CAPN3 polypeptide and is intended for Western blot (WB) workflows on human, mouse, and rat samples.

The antibody is supplied as 50 µl of polyclonal serum-derived IgG, compatible with HRP-conjugated or fluorescent secondary detection on standard immunoblots. Polyclonal recognition supports binding to multiple epitopes across the calpain-3 protein, which is helpful when probing full-length CAPN3 in skeletal muscle lysates.

Researchers studying LGMD2A pathology, muscle proteostasis, exercise-induced proteolysis, or dystrophin-associated glycoprotein complex integrity in mouse models often use CAPN3 immunoblotting. The unconjugated format from Antibodies.com allows flexible pairing with rabbit-compatible secondary reagents in custom multiplex or stripping-reprobe protocols.