Anti-CAPN3 Antibody

Calpain-3 (CAPN3, also known as p94) is a muscle-specific calcium-activated cysteine protease whose unusually rapid autolytic turnover sets it apart from other calpain isoforms, and loss-of-function mutations in the CAPN3 gene cause limb-girdle muscular dystrophy type 2A (LGMD2A/R1). This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against CAPN3 and supplied as 100 µl of polyclonal antiserum for research use only. Validated for western blot detection in human, mouse, and rat samples, the antibody recognizes endogenous CAPN3 in lysates from myogenic cell culture and skeletal muscle biopsy tissue, allowing researchers to resolve full-length p94 alongside its characteristic processed fragments. It supports work on sarcomere remodeling, muscle protein turnover, dystrophinopathies, and skeletal muscle proteostasis, including comparative studies of the protease's regulatory cleavage events that govern its activity in striated muscle.