Anti-CAP2 Antibody

Affinity-purified rabbit polyclonal reagent against CAP2 (Adenylyl Cyclase-Associated Protein 2), supplied by Antibodies.com as an unconjugated IgG in a 50 µl liquid aliquot. The antibody recognizes endogenous CAP2 protein across human, mouse, and rat samples and has been validated for western blot and immunohistochemistry workflows, including staining of paraffin-embedded tissue sections. CAP2 is a conserved regulator of actin filament turnover belonging to the cyclase-associated protein family; it is expressed predominantly in brain, cardiac muscle, skeletal muscle, skin, and testis, where it controls pointed-end actin dynamics in cardiomyocytes and shapes dendritic spine morphology and synaptic plasticity in neurons. Published studies have linked CAP2 loss to dilated cardiomyopathy, delayed wound healing, and altered cytoskeletal remodeling, while its dysregulation has been reported in certain tumor types. Researchers apply this reagent to investigations of sarcomeric assembly, cell motility, and signaling connected to adenylyl cyclase activity. The product is formulated in PBS buffer (pH 7.3) containing 0.05% sodium azide and 50% glycerol, and should be stored refrigerated; avoid repeated freeze-thaw cycles to preserve immunoreactivity. For research use only.