Anti-CaMKII delta Antibody

Produced in rabbit as a polyclonal reagent and supplied unconjugated for flexible detection chemistry, this Antibodies.com primary antibody targets the δ isoform of calcium/calmodulin-dependent protein kinase II (CAMK2D). Each vial contains 100 µl of antiserum validated for western blot and immunofluorescence applications on human samples.

CaMKIIδ is best known for its role in cardiomyocyte calcium handling and contractile regulation, where aberrant autophosphorylation at Thr287 contributes to arrhythmia susceptibility, maladaptive hypertrophy, and progression toward heart failure. Investigators studying diabetic cardiomyopathy, ischemic injury, or beta-adrenergic signaling cascades routinely probe CaMKIIδ expression and modification in cardiac tissue, while neurobiology labs examine the same isoform in synaptic plasticity and neuronal excitability contexts. The polyclonal format helps preserve multiple epitopes, supporting detection even when post-translational modifications or isoform splice variants might mask a single monoclonal epitope.

For western blot, dilute in blocking buffer and pair with HRP-conjugated secondary antibodies; for IF, combine with fluorescently labeled secondaries on fixed cells or tissue cryosections. Store at -20 °C and aliquot upon receipt to minimize freeze-thaw cycles, with brief 4 °C handling during active use periods.