Anti-CaMKII (Ab-286) Antibody

A rabbit polyclonal reagent from Antibodies.com, this phospho-specific antibody selectively recognizes calcium/calmodulin-dependent protein kinase II (CaMKII) only when threonine 286 carries the activating autophosphorylation mark that locks the kinase into a calcium-independent active state. The modification is a central node in hippocampal long-term potentiation, cardiac excitation-contraction coupling, and excitotoxic neuronal injury, making the reagent broadly useful across neuroscience and cardiology workflows. Supplied unconjugated in a 100 µL vial, the antibody is compatible with fluorescent, chromogenic, or HRP-conjugated secondaries depending on the assay design. Validated applications include Western blot for tracking phospho-kinase abundance across tissue lysates and immunofluorescence for visualizing kinase localization at postsynaptic densities, nuclear puncta, and sarcomeric regions. Reactivity has been confirmed in human, mouse, and rat samples. For routine use the antibody should be kept refrigerated; small-volume aliquots minimize repeated freeze-thaw cycles and preserve performance across longitudinal studies.