Anti-CaMKIIα (K292) Antibody

CaMKIIα (Calcium/calmodulin-dependent protein kinase II alpha) is a serine/threonine kinase central to calcium-dependent signaling in neurons, where it contributes to synaptic strengthening, learning, and memory processes. This primary antibody from Antibodies.com is a rabbit polyclonal reagent raised against the K292 region of CaMKIIα, enabling detection of endogenous kinase expression and modification state in neural tissue and cell-based systems.

The antibody is provided as 100 µl of unconjugated reagent at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at roughly pH 7.2. It is validated in Western blot (WB) and immunohistochemistry (IHC), with reactivity confirmed against human, mouse, and rat samples, supporting cross-species work in rodent models and human specimens.

For handling, store the vial at 4°C for short-term use; for longer periods, aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles to preserve antibody activity. The sodium azide content inhibits microbial growth during routine handling at the bench.

Typical uses span neuroscience, signal transduction, and cell biology laboratories studying CaMKII-dependent pathways, where this polyclonal reagent detects CaMKIIα in tissue sections and protein lysates for studies of synaptic plasticity, neuronal activity-dependent regulation, and related signaling networks.