Anti-CALR Antibody

Calreticulin (CALR) is a 46 kDa calcium-binding chaperone that resides in the endoplasmic reticulum lumen, where it guides glycoprotein folding, regulates intracellular calcium homeostasis, and participates in quality-control pathways for newly synthesized proteins.

Distributed by Antibodies.com as an unconjugated rabbit polyclonal reagent, this antibody is raised against CALR and validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows, with confirmed reactivity against human, mouse, and rat samples. The 50 µl aliquot is supplied as a liquid in a vial and pairs cleanly with HRP-, biotin-, or fluorophore-conjugated secondary antibodies for flexible detection in any lab setup.

Researchers studying unfolded protein response signaling, ER stress, antigen presentation, and myeloproliferative neoplasm biology, where somatic CALR mutations such as the common type-1 52 bp deletion in exon 9 serve as a clonal diagnostic marker, commonly rely on this reagent. Aliquot upon arrival and store refrigerated to preserve polyclonal titer across repeated freeze-thaw cycles.