Anti-Calpain-5 Antibody

Calpain-5 is a calcium-dependent cysteine protease of the non-classical calpain family, implicated in retinal cell homeostasis, neuronal signaling, and the regulation of autophagy. Mutations in the CAPN5 gene have been linked to autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), making reliable detection tools important for vision research and neurobiology studies.

This polyclonal reagent from Antibodies.com is raised in rabbit and supplied as 100 µl of unconjugated antiserum. It is validated for Western blot and immunofluorescence applications on human samples, supporting studies of protein expression, subcellular localization, and pathway analysis in cell and tissue models expressing endogenous Calpain-5. The unconjugated format allows flexible secondary antibody pairing across fluorescence and chromogenic detection chemistries in individual laboratory workflows.

The antibody is provided in a single-use vial format and is intended for research use only. Short-term handling at refrigerated temperature is recommended, with working aliquots prepared to minimize repeated freeze-thaw cycles and preserve reagent stability across multiple experiments.