Anti-CALCB Antibody

Produced in rabbit hosts as an unconjugated polyclonal IgG, this Antibodies.com reagent targets calcitonin-related polypeptide beta (CALCB), a member of the calcitonin gene peptide family encoded by the CALCB gene. CALCB gives rise to beta-CGRP, a neuropeptide expressed across central and peripheral neurons where it shares overlapping but distinct functions with its paralog encoded by CALCA, contributing to nociceptive signaling, vasodilation, and the trigeminovascular pathways studied in migraine biology.

Validated for Western blot (WB) and immunohistochemistry (IHC), the antibody cross-reacts with Human, Mouse, and Rat samples, supporting comparative work across rodent disease models and human tissue cohorts. The unconjugated format leaves detection chemistry to the researcher, allowing pairing with HRP, fluorescent, or biotinylated secondaries. Each preparation is supplied at 200 µl and should be stored frozen at -20°C, with working aliquots reserved to limit freeze-thaw cycling and protect lot performance over time.

CALCB expression has been reported in the nervous system, pituitary, and select endocrine compartments, making this reagent a useful probe for studies of neurogenic inflammation, peptide receptor pharmacology, and the broader calcitonin gene peptide superfamily. For IHC, optimize antigen retrieval to the formalin-fixed preparation; for WB, run under standard reducing SDS-PAGE conditions prior to transfer.