Anti-CACNG2 Antibody

The Anti-CACNG2 antibody recognizes stargazin, the gamma-2 auxiliary subunit of voltage-gated calcium channels that governs AMPA receptor trafficking and stabilization at excitatory glutamatergic synapses. Originally characterized through the stargazer mouse model of absence epilepsy, this membrane regulatory protein is now widely investigated for its links to seizure susceptibility, schizophrenia risk loci, neurodevelopmental signaling, and activity-dependent synaptic plasticity.

Antibodies.com provides this reagent as 100 µl of unconjugated rabbit polyclonal antiserum, validated for Western blot and immunofluorescence on human samples. Researchers use it to probe channel subunit composition in postmortem brain tissue, confirm CRISPR-edited knockout of CACNG2 in neuronal cell lines, and profile stargazin redistribution following chemogenic or electrophysiological stimulation paradigms.

Typical applications include immunohistochemistry on rodent and human brain sections to map stargazin localization at dendritic spines, co-immunoprecipitation with GluA1 or PSD-95 to interrogate AMPA receptor complexes, and cell-based immunofluorescence in iPSC-derived neurons carrying epilepsy or psychiatric risk variants. The polyclonal format provides broader epitope coverage for detecting splice isoforms and post-translational modifications.