Anti-CACNA1E Antibody

Voltage-gated calcium channels containing the α1E subunit, encoded by the CACNA1E gene, mediate R-type calcium currents that shape neuronal firing, neurotransmitter release, and synaptic integration. The polyclonal reagent supplied by Antibodies.com is raised in rabbit and delivered as a 100 µL vial at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide, intended for western blot detection of the pore-forming subunit across human, mouse, and rat samples.

In research, this reagent has been used to investigate Cav2.3 channel expression in brain regions including the cerebellum, cortex, and hippocampus, where R-type currents are particularly prominent. Published work has linked CACNA1E variants to developmental and epileptic encephalopathies, neurodevelopmental disorders, and altered pain perception, making it a relevant target for neuroscience and ion-channel pharmacology studies. The unconjugated format gives flexibility with secondary antibody selection, while the verified reactivity with human, mouse, and rat enables cross-species comparisons in cell culture and tissue lysate workflows. For storage, refrigerate in the supplied buffer to maintain antibody activity and avoid repeated freeze-thaw cycles.