Anti-CABYR Antibody

Raised in rabbit against the calcium-binding tyrosine phosphorylation-regulated (CABYR) protein, this polyclonal primary reagent from Antibodies.com is supplied as a 100 µl aliquot at 1 mg/ml in phosphate buffered saline (approximately pH 7.2) with 0.05% sodium azide added as a preservative. The unconjugated antibody is validated for western blot detection of endogenous CABYR in human, mouse, and rat samples, supporting investigators working on sperm flagellar assembly, capacitation, and the broader biology of CABYR splicing variants in neural and tumor tissues.

CABYR is best characterized as a testis-enriched phosphoprotein localized to the fibrous sheath of the sperm flagellum, where its RIIa-like domain and EF-hand calcium-binding motifs contribute to motility and hyperactivation. More recent studies have expanded its relevance beyond reproductive biology, documenting expression in brain tissue and identifying CABYR isoforms as candidate antigens for cancer-testis immunotherapy and as potential biomarkers in glioma research. The vial should be stored refrigerated and protected from light to preserve binding activity through the standard shelf life, and the reagent is intended for research use only.