Anti-CA5B Antibody

The target CA5B encodes mitochondrial carbonic anhydrase 5B, an enzyme that catalyzes the reversible hydration of carbon dioxide and supports key biosynthetic pathways, including gluconeogenesis and ureagenesis. Expressed predominantly in liver, kidney, and pancreatic tissues, CA5B contributes to mitochondrial acid-base balance, bicarbonate supply for carboxylation reactions, and broader metabolic function.

Supplied by Antibodies.com, this polyclonal reagent is raised in rabbit, formulated as IgG, and provided unconjugated in a 100 µl volume. It is validated for Western blot, immunohistochemistry, and flow cytometry on both human and mouse samples, allowing detection of endogenous CA5B protein in cell lysates, fixed tissue sections, and single-cell suspension preparations.

The polyclonal format provides epitope diversity, improving recognition of the target even when expression is low or the antigen is partially modified. Investigators studying mitochondrial metabolism, hepatic and renal physiology, obesity-linked metabolic dysfunction, tumor microenvironment biology, and the broader carbonic anhydrase family will find this antibody useful for expression profiling, target validation, and comparative studies across species.