Anti-CA4 Antibody

Carbonic anhydrase 4 (CA4) is a GPI-anchored zinc metalloenzyme expressed on the apical surface of epithelial cells in the kidney proximal tubule, lung, and gastrointestinal tract, where it participates in bicarbonate reabsorption and acid-base balance. This rabbit polyclonal antibody from Antibodies.com is raised against CA4 and validated for western blot and immunohistochemistry on human and mouse samples. Supplied as 100 µl of unconjugated antiserum, the reagent lets investigators detect endogenous CA4 in tissue sections and lysates without a secondary label, supporting studies of renal physiology, glaucoma-associated CA4 variants, and tumor microenvironments where CA4 expression has been reported. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which is useful when probing low-abundance targets or when sample fixation partially masks the recognition site. Researchers commonly apply the antibody to western blot membranes and to formalin-fixed paraffin-embedded tissue sections for IHC, with working dilutions optimized per application.