Anti-CA4 Antibody

Raised in rabbit and validated for Western blot, this polyclonal IgG antibody targets carbonic anhydrase 4 (CA4), a glycosylphosphatidylinositol-anchored zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide and helps regulate pH and ion balance across epithelial tissues. The reagent is supplied as 100 µl of unconjugated serum and has been verified to cross-react with both human and mouse CA4, allowing comparative studies across species using a single preparation. Endogenous CA4 expression is well documented on the apical surface of kidney proximal tubules, on capillary endothelium, and along gastrointestinal epithelium, and loss-of-function mutations in the encoding gene have been linked to retinitis pigmentosa type 17 (RP17), giving the target clear relevance for retinal and renal research projects. From Antibodies.com, the antibody is shipped frozen and should be stored at -20 °C in working aliquots to limit repeated freeze-thaw cycles, with brief refrigeration on wet ice sufficient for short-term handling during ongoing western blot work.