Anti-C10orf2 Antibody

The C10orf2 gene encodes Twinkle, a mitochondrial DNA helicase essential for mtDNA replication and stability. This polyclonal reagent from Antibodies.com is raised in rabbit and binds the native human protein, supporting investigations into disorders linked to mitochondrial genome maintenance, including autosomal dominant progressive external ophthalmoplegia and Perrault syndrome.

Applied in Western blot analysis of cell lysates and immunohistochemistry on fixed tissue sections, the unconjugated preparation enables flexible choice of secondary label and detection chemistry. The 100 µl volume is supplied in a vial format for research laboratories running membrane-based or chromogenic assays. Host species reactivity is specific to human samples, which aligns with studies characterizing patient-derived fibroblasts and skeletal muscle biopsies for respiratory chain defects.

For best results, aliquot upon arrival to limit freeze-thaw exposure and store at -20°C protected from light until first use. Each lot supports reproducible band identification around the expected molecular weight of the Twinkle helicase, making it useful for confirming expression changes across patient and control cohorts. This research-use-only reagent complements genetic studies of mtDNA depletion and bridges genotype-to-phenotype analyses in mitochondrial disease research.