Anti-C10orf2 Antibody

From Antibodies.com, this rabbit polyclonal primary antibody targets C10orf2, the nuclear gene that encodes Twinkle, a hexameric helicase required for mitochondrial DNA replication and stability. The unconjugated reagent is supplied as 100 µl of liquid and is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows. It cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies of mtDNA maintenance across model organisms and patient-derived tissues. Researchers use C10orf2 detection to investigate Twinkle expression in disorders linked to mitochondrial DNA depletion, multiple deletions, and progressive external ophthalmoplegia, as well as in basic studies of replisome assembly at mitochondrial nucleoids. Storage at -20 °C in aliquots preserves activity across repeated freeze-thaw cycles, and the polyclonal format provides epitope redundancy useful when probing conserved variants of Twinkle. For research use only.