Anti-c-Myc Antibody

This rabbit polyclonal antibody from Antibodies.com targets the c-Myc transcription factor encoded by the MYC proto-oncogene, a basic helix-loop-helix leucine zipper protein that regulates cell cycle progression, apoptosis, and metabolic reprogramming. Supplied as 100 µl of unconjugated antiserum in a single-use vial, the reagent is validated for western blot detection of endogenous and overexpressed c-Myc in human, mouse, and rat samples, as well as immunohistochemistry on formalin-fixed paraffin-embedded tissue sections and immunofluorescence imaging of cultured cells. Researchers commonly apply this reagent to investigate MYC-driven oncogenesis in lymphoma and colorectal carcinoma models, to monitor exogenous Myc-tagged fusion proteins in transfected lines, and to probe proliferative signaling in stem cell and developmental biology studies. The polyclonal format increases the likelihood of recognizing multiple epitopes across the conserved N-terminal transactivation region, which can be advantageous when probing samples where the target may be partially degraded or post-translationally modified. Aliquot upon arrival and store at -20 degrees C in working volumes to limit freeze-thaw cycles and preserve binding activity over extended studies.