Anti-c-Jun (Ab-243) Antibody

The c-Jun protein forms the core of the activator protein-1 (AP-1) transcription factor complex, dimerizing with JunB, JunD, or Fos family partners to drive genes controlling proliferation, differentiation, and apoptosis. This Antibodies.com rabbit polyclonal reagent targets the Ab-243 region of human c-Jun, a stretch that includes the Ser243 residue phosphorylated by casein kinase II, a modification that modulates AP-1 transcriptional output. Researchers apply the antibody to Western blot detection of c-Jun in lysates from growth-factor or stress-stimulated cells, and to immunohistochemistry on formalin-fixed tissue sections to map Jun expression across normal and tumor samples. Because the reagent is supplied unconjugated, it adapts readily to HRP, biotin, or fluorophore detection chemistries chosen by the end user.

For best stability, the 100 µl liquid vial should be aliquoted upon arrival and stored at -20°C, with working stocks kept refrigerated at 4°C for short-term use and protected from light once modified. Avoid repeated freeze-thaw cycles of the aliquoted antibody. Reported reactivity against human c-Jun makes this reagent useful for studies of stress-activated kinase cascades, oncogenic transformation, neuronal injury responses, and AP-1 activity in developmental or disease models.